Ray Winter (Kyle MacLachlan) leaves his wife, Carly (Maria Bello), for another man. Ray's popular, athletic son, Franky (Josh Wiggins), refuses to talk to his father despite Ray's pleas.
Franky Winter (Josh Wiggins) and Ballas Kohl (Darren Mann) have been best friends since childhood. They are high school royalty: handsome, stars of the swim team and popular with girls. They live a perfect teenage life – until the night of Franky's epic 17th birthday party, when Franky and Ballas are involved in an unexpected incident that changes their lives forever.
Franky begins to piece his life back together by befriending potentially transgender friend Mouse (Niamh Wilson). He also rekindles his friendship with Ballas' sister, Natasha (Taylor Hickson), whom everyone (including Franky) ostracized some time ago as a "slut" after she had sex with another boy. Franky finds himself romantically involved with Natasha. Franky realizes that being pushed into a straight relationship is just as bad as being bullied for being gay, and that he should put off a serious relationship or sex until he's ready. The insight helps Franky come to terms with his father's homosexuality.
Giant Little Ones is a heartfelt and intimate coming-of-age story about friendship, self-discovery and the power of love without labels.